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2025-26 NFL Week 4 Preview - Seattle vs. Arizona:
Will the Seahawks continue their dominance over the Cardinals?

September 25, 2025 by Marc Jerbs

The Seattle Seahawks will visit the Arizona Cardinals in a Week 4 divisional matchup at State Farm Stadium on Thursday, September 25, 2025. Kickoff is scheduled for 8:15 PM EDT. This marks Arizona's second straight NFC West game and its first Thursday Night Football appearance since a 2022 victory over New Orleans. The contest will be the eighth primetime meeting between these rivals and their fourth clash on a Thursday night stage.

Seattle Seahawks: Building Momentum Early

The Seahawks enter Week 4 with a 2-1 record after securing wins over the Steelers and Saints. Their only loss came against the San Francisco 49ers, but Seattle rebounded with a commanding 44-13 victory over New Orleans.

Offensive Outlook

Quarterback Sam Darnold has been efficient, completing 70.3% of his passes for 663 yards, 4 touchdowns, and 2 interceptions. His accuracy currently ranks sixth in the NFL.

• Jaxon Smith-Njigba leads the receiving corps with 323 yards and 1 touchdown on 22 catches.
• Cooper Kupp has provided veteran consistency, while Tory Horton has made an impact with 2 touchdowns and a 95-yard punt return score.
• On the ground, Kenneth Walker III leads the rushing attack with 163 yards and 3 touchdowns, helping Seattle average 96 rushing yards per game.

Defensive Outlook

Seattle's defense ranks among the league's best, allowing only 15.7 points per game—second in the NFL.

• Ernest Jones IV leads the team with 25 tackles.
• Byron Murphy II has posted 2.5 sacks.
• Derion Kendrick has 2 interceptions.

The unit has held opponents under 18 points in every game this season, showcasing balance against both the run and pass.

Seattle vs. Arizona Sports Bet Odds

The Seahawks are the favorites to win the game. Here are our latest odds:

• The Seahawks are favored by 1.5 points, with a money line of -130.
• The Cardinals are the underdogs by 1.5 points, with a money line of +110.
• The Total is set at 43 points, with the Over at -115 and the Under at -105.

Arizona Cardinals: Searching for Consistency

Arizona also sits at 2-1 after wins over the Panthers and a narrow 16-15 loss to the 49ers in Week 3.

Offensive Outlook

Quarterback Kyler Murray continues to drive the Cardinals' offense, completing 67.4% of his passes for 542 yards, 4 touchdowns, and 1 interception while adding 107 rushing yards.

• Trey McBride has 182 receiving yards and 1 touchdown.
• Rookie Marvin Harrison Jr. has added 142 yards and 1 score.
• Trey Benson leads the ground game with 125 yards on 21 carries, though Arizona has struggled to maintain rushing efficiency late in games.

Defensive Outlook

The Cardinals' defense has been solid, allowing 17 points and 340.7 yards per game while excelling against the run.

• Mack Wilson Sr. leads with 28 tackles.
• Calais Campbell has 2 sacks.
• Baron Browning has 1 interception.

The front seven could be key against Seattle's inconsistent ground game.

Seattle vs. Arizona Injury Report

Seattle Seahawks

• Out: OT Josh Jones (ankle)
• Doubtful: S Nick Emmanwori (ankle)
• Questionable: RB Zach Charbonnet (foot), LB Boye Mafe (toe), G Anthony Bradford (back)
• Cleared: CB Devon Witherspoon (knee), S Julian Love (hamstring)
• Injured Reserve: FB Robbie Ouzts (ankle)

Arizona Cardinals

• Out: RB James Conner (foot), WR Zay Jones (concussion)
• Doubtful: CB Will Johnson (groin)
• Questionable: OT Paris Johnson Jr. (knee), G Will Hernandez (knee), OT Kelvin Beachum (knee/rest), G Evan Brown (ankle), LB Akeem Davis-Gaither (elbow), CB Darren Hall (ankle)

Historical Matchup Trends

Seattle has dominated recent meetings, winning seven straight games against Arizona, including four consecutive at State Farm Stadium. The Seahawks hold a 29-22-1 all-time series advantage. The Cardinals last defeated Seattle in November 2021.

Under head coach Jonathan Gannon, Arizona has averaged just 13.5 points per game against the Seahawks and has not scored more than 21 points in their last six meetings. Seattle, meanwhile, has excelled as a road underdog, winning its last five games in that role.

Final Thought

Both teams enter this matchup with identical 2-1 records, but Seattle's defensive consistency and balanced offense may provide an edge. The Cardinals will rely on Kyler Murray's dual-threat ability and a strong run defense to challenge the Seahawks. With recent history favoring Seattle, this Thursday night contest will test whether Arizona can break the trend or if the Seahawks will extend their dominance in the NFC West rivalry.

2025-26 Seattle vs. Arizona Team Stats

SEATTLE SEAHAWKS	VS	ARIZONA CARDINALS
T-2nd NFC West (2-1) Away (1-0) | STRK W2	Standings	T-2nd NFC West (2-1) Home (1-0) | STRK L1
219.0	Passing Yards Per Game	165.0
96.0	Rushing Yards Per Game	111.3
29.3	Points Per Game	20.7
221.7	Passing Yards Allowed Per Game	264.3
90.0	Rushing Yards Allowed Per Game	76.3

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